Blood substitutes based on nanobiotechnology
نویسندگان
چکیده
منابع مشابه
Blood substitutes based on nanobiotechnology.
Stimulated by concerns of potential infective agents in donated blood, commercial enterprises have attempted to develop blood substitutes since the 1900s. After several years of development, a few of the many leads are showing promise. In this article, nanobiotechnological approaches that are now in phase III clinical trials are reviewed, followed by a discussion of how important basic knowledg...
متن کاملNanobiotechnology for hemoglobin-based blood substitutes.
Nanobiotechnology is the assembling of biological molecules into nanodimension complexes. This has been used for the preparation of polyhemoglobin formed by the assembling of hemoglobin molecules into a soluble nanodimension complex. New generations of this approach include the nanobiotechnological assembly of hemoglobin, catalase, and superoxide dismutase into a soluble nanodimension complex. ...
متن کامل5 Nanobiotechnology - based Blood Substitutes and the Cardiovascular Systems in Transfusion Medicine Thomas Ming
Red blood cell membrane contains blood group antigens, and typing and matching are needed before donor blood can be transfused into patients. This results in delays in emergency situations. Donor blood requires storage at 4oC using standard methods and is good for less than 42 d. Red blood cells cannot be sterilized to remove hepatitis viruses, HIV and other potential emerging infective agents....
متن کاملHemoglobin-based red blood cell substitutes.
Polyhemoglobin is already well into the final stages of clinical trials in humans with one approved for routine clinical use in South Africa. Conjugated hemoglobin is also in ongoing clinical trials. Meanwhile, recombinant Hb has been modified to modulate the effects of nitric oxide. Other systems contain antioxidant enzymes for those clinical applications that may have potential problems relat...
متن کاملBlood substitutes
Blood substitutes have long been sought after, and artificial oxygen carriers may soon become a reality. Despite increased safety of allogeneic blood in terms of transmission of infectious diseases [1], avoiding allogeneic blood transfusions remains an important goal in perioperative and intensive care medicine. This is because allogeneic blood transfusions may cause immunosuppression with an i...
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ژورنال
عنوان ژورنال: Trends in Biotechnology
سال: 2006
ISSN: 0167-7799
DOI: 10.1016/j.tibtech.2006.06.005